Human ASPDH is a 2-aminomuconate reductase that produces L-2-aminohex-3-enedioic acid in tryptophan catabolism
Giulia Sassi, Giulia Mori, Serena Facchetti, José Fernando Rinaldi de Alvarenga, Marina Simona Robescu, Elena Dembech, Marco Vezzoli, Giovanni Merici, Marco Malatesta, Sara Dobani, Daniele Del Rio, Letizia Bresciani, Giacomo Quilici, Davide Cavazzini, Roberto Battistutta, , Riccardo Percudani
The paper identifies human ASPDH as a 2-aminomuconate reductase in tryptophan catabolism, revealing a new branch of the kynurenine pathway and an unknown amino acid.
bioRxiv · Jun 9, 2026 · PreprintBiochemistry