Marco Malatesta

This study identifies COQ8 as a chaperone that facilitates coenzyme Q biosynthesis by ATP-driven structural gating of intermediates.

The paper identifies L2HGDH as a component of the COQ metabolon, linking L-2-hydroxyglutarate recycling to coenzyme Q biosynthesis and showing its role in maintaining biosynthetic intermediates.

The paper investigates how metabolon clustering enhances coenzyme Q biosynthesis through substrate channeling using simulations and experiments.

The paper identifies human ASPDH as a 2-aminomuconate reductase in tryptophan catabolism, revealing a new branch of the kynurenine pathway and an unknown amino acid.

This study shows that 3D culture of breast cancer cells alters chromatin structure and gene expression, with LATS1 kinase playing a key role in CTCF displacement and hormonal response.