Genome-wide loss of chromatin accessibility coexists with selectively elevated RNA abundance in nutrient-starved U2OS cells
Xiyuan Qi, Sham Armouch Al Refaai, Sergei Muslinov, Konstantin Panov
This study shows that during nutrient starvation, chromatin accessibility decreases genome-wide, but RNA abundance increases selectively in stress-adaptive genes, indicating limited predictive power of ATAC-seq for transcript abundance.
bioRxiv · Nov 3, 2026 · PreprintBioinformatics