Interactions between tick-borne encephalitis virus non-structural protein 1 and blood-brain barrier tight junction proteins: potential clues to strain-specific neuropathogenicity
Jason Chun Sang Pun, Jarinya Chaopreecha, Jordan Liburd, Shahid Khalid, Ian Martin Jones, Jennifer H. Tomlinson, Niluka Goonawardane
This study investigates how NS1 proteins from high- and low-pathogenicity TBEV strains interact with BBB tight junction proteins, revealing strain-specific binding patterns that may explain differential neuropathogenicity.
bioRxiv · Aug 12, 2025 · PreprintMicrobiology