A CD40-Targeted IL-21 Fusokine Enables Rapid Generation of Human IL-10⁺Granzyme B⁺ Regulatory B Cells
Andrea Pennati, Shala Yuan, Rahul Das, Catigan A. Hedican, Amar M. Yeware
This paper demonstrates that a CD40-targeted IL-21 fusion protein and TLR9 activation can induce a stable regulatory B cell phenotype in human B cells with high efficiency.
Scientific Reports · Sep 2, 2026Peer-reviewedImmunology