Shankar Shastry

Protein solubility depends on centrifugation: Aiki-Sol, a per-regime predictor for E. coli

The paper introduces Aiki-Sol, a predictor for E. coli protein solubility that accounts for centrifugation regimes, improving performance by treating regime as a feature rather than noise.

Aiki-GeNano: Multi-Stage Preference Optimization for Generative Design of Developable Nanobodies

Aiki-GeNano improves nanobody design by integrating developability signals into training, enhancing thermal stability and reducing liabilities while preserving humanness.

Aiki-XP: leakage-controlled multimodal prediction of within-species relative protein expression at pan-bacterial scale

Aiki-XP predicts within-species relative protein expression across bacteria using multimodal data, outperforming single-omics models in leakage-controlled settings.

High accuracy DNA sequencing on a small, scalable platform via electrical detection of single base incorporations

This paper introduces an electronic detection-based DNA sequencing platform that achieves high accuracy and scalability for microbial and human genome sequencing.

Engineered kinesin motor proteins amenable to small molecule inhibition

This paper engineers kinesin motors to be inhibited by small molecules, enabling specific study of their functions.