Cross-Tissue Inflammatory Convergence Supports a Putative Muscle-Brain Axis in Alzheimer's Disease
Andong Zhang, Wei Shen, Shijun Yan, Jing Chen, Xiaoyan Liu, Jingfeng Zou, Shaotian Li, Shanshan Hu, Yiting Liu, Catherine Pan, Zhuoqing Lan, Guoping Peng, Qin Zhang, Wen Peng, Fariba Ahmadizar, , the Alzheimer’s Disease Neuroimaging Initiative
The paper identifies shared inflammatory pathways between aging skeletal muscle and Alzheimer's disease brain tissue, detectable in peripheral blood, and prioritizes candidate regulators.
bioRxiv · Oct 8, 2026 · PreprintNeuroscience