Jing Zhang

Phenotypic structure and genetic correlates of adolescent psychiatric symptomatology in versus out of autism

The paper compares the phenotypic and genetic structures of psychiatric symptoms in autistic and non-autistic children, finding differences in factor structures and genetic associations.

Cross-Tissue Inflammatory Convergence Supports a Putative Muscle-Brain Axis in Alzheimer's Disease

The paper identifies shared inflammatory pathways between aging skeletal muscle and Alzheimer's disease brain tissue, detectable in peripheral blood, and prioritizes candidate regulators.

Prediction of ROR1 and CAV1 expression from whole-exome sequencing of tumor tissue and plasma cfDNA to infer the efficacy of B013 plus nab-paclitaxel in triple-negative breast cancer

The paper predicts ROR1 and CAV1 expression from whole-exome sequencing data to assess response to B013 plus nab-paclitaxel in triple-negative breast cancer, showing agreement with observed responses in 9 out of 10 patients.

AI-Based Comparison of UniProt annotations and Literature Across Human Kinases

The paper uses AI to compare biological information from UniProt records and their cited literature for human kinases, finding literature provides better coverage for certain topics.

Substrate Profiling of RNF216 Uncovers a Translation-Linked OTUD4 Regulatory Axis

The paper identifies RNF216 and OTUD4 as regulators of protein synthesis and degradation, showing their interaction disrupts neurodegeneration in Gordon Holmes syndrome.

Domain classification of archaeal proteomes reveals conserved fold repertoire

The paper classifies archaeal proteomes at the domain level, revealing that structural diversity is conserved across archaea and that unclassified proteins are due to classification limitations, not structural novelty.

Transthyretin Contributes to Hippocampal Blood-Brain Barrier Recovery Following Intestinal Inflammation, with Reduced Expression in Alzheimer's Disease

The paper investigates how intestinal inflammation affects the blood-brain barrier (BBB) and identifies transthyretin (TTR) as a key factor in BBB recovery, with reduced TTR expression linked to Alzheimer's disease.

Ribonucleotide Reductase Inhibition Overcomes FLT3 Inhibitor Resistance in Acute Myeloid Leukemia

This paper identifies RNR inhibition as a strategy to overcome FLT3 inhibitor resistance in FLT3ITD+ AML by reversing resistance mechanisms and enhancing therapeutic efficacy.

OLD sentinel: an abortive tRNase surveys phage replication and DNA defects in RecBCD-compromised cells

This paper characterizes OLD, an abortive immunity protein, revealing its structure and activation mechanism in response to phage replication and DNA defects in RecBCD-compromised cells.

Targeted Photodegradation of Misfolded Proteins via Self-photosensitizing with Molecularly Produced Light

This study demonstrates that molecularly produced light from ADLumin-5 can degrade misfolded proteins like beta-amyloid and reduce their toxicity in vitro and in vivo.

Structural basis of long-range transcription-translation coupling

The paper reports structures of long-range coupled transcription-translation complexes (TTC-LC) in E. coli, showing how they differ from TTC-B and their roles in transcription-translation coupling.

The abscopal effect of Combination IRE with anti-PD-1 achieves local ablation and systemic control of PDAC

This paper shows that combining IRE with anti-PD-1 induces abscopal effects in PDAC by triggering immune activation and systemic antitumor responses.

ECOD: Classification of domains in AFDB Swiss-Prot structure predictions

The paper classifies over 542,000 Swiss-Prot protein structure predictions into ECOD domains, expanding domain coverage and revealing novel evolutionary groups.

Dual functions of apigenin in suppressing Phytophthora capsici and shaping the pepper microbiome

This study shows apigenin enhances pepper resistance to Phytophthora capsici by inhibiting pathogen growth and promoting beneficial microbiota.

Microhomology-Mediated Tandem Duplication Drives Tandem Repeat Formation Across Life

This study identifies microhomology-mediated tandem duplication (MTD) as a universal mechanism for tandem repeat formation across all domains of life, including human pathogenic mutations.

Transforming Histology into Virtual Multiplex Immunofluorescence to Decode Prognostic Spatial Immunity in Hepatocellular Carcinoma

HCCExplorer translates H&E slides into virtual multiplex immunofluorescence to identify prognostic spatial immune features in hepatocellular carcinoma.

Unwinding of RNA G-quadruplexes induces mouse and human totipotency

This study shows that unwinding RNA G-quadruplexes with FC3 induces and maintains totipotency in mouse and human cells, recapitulating 2-cell-stage features and enabling differentiation into embryonic and extraembryonic lineages.

Type one protein phosphatases (TOPPs) catalyze EIN2 dephosphorylation to regulate ethylene signaling in Arabidopsis

This study identifies TOPPs as regulators of ethylene signaling in Arabidopsis by dephosphorylating EIN2, enhancing its stability and nuclear accumulation, and improving salt tolerance.

Quercetin selectively reduces expanded repeat RNA levels in models of myotonic dystrophy

Quercetin reduces toxic RNA levels and rescues MBNL-dependent mis-splicing in DM1 and DM2 models.

Selective Enhancement of the Interneuron Network and Gamma-Band Power via GluN2C/GluN2D NMDA Receptor Potentiation

This paper describes a GluN2C/GluN2D-selective NMDA receptor modulator that enhances inhibitory interneuron activity and gamma-band power, with potential therapeutic applications for neuropsychiatric disorders.

Loss function of tumor suppressor FRMD8 confers resistance to tamoxifen therapy via a dual mechanism

This study identifies FRMD8 as a regulator of ER levels in ER-positive breast cancer, showing it confers tamoxifen resistance through dual mechanisms involving transcriptional and post-translational regulation of ER.

Biomimetic graphitic carbon nitride nanoparticles enable multiscale biomodulation

This paper introduces biomimetic graphitic carbon nitride nanoparticles that enable multiscale photo-modulation of cells and tissues through light-responsive mechanisms.

Locus-specific stratification and prioritization unveil high risk genes underlying hyperuricemia

This study introduces a method to identify causal genes and regulatory mechanisms in hyperuricemia by integrating single-cell data with genetic findings.

The Amyloid Structure of Mouse RIPK3 (Receptor Interacting Protein Kinase 3) in Cell Necroptosis

This study structures and functionally characterizes the mouse RIPK3 amyloid complex in necroptosis, revealing a unique N-shaped core and a structural transformation from hetero- to homo-oligomer.

Kindlin2-mediated phase separation underlies integrin adhesion formation

This study shows that kindlin2-mediated phase separation facilitates integrin adhesion formation by enabling condensate assembly and integrin activation.

Inferring transcriptional regulators through integrative modeling ofpublic chromatin accessibility and ChIP-seq data

Lisa predicts transcriptional regulators of gene sets by integrating chromatin accessibility and ChIP-seq data to identify relevant regulators.

The Clinical Significance and Biological Function of DPEP1 in B-cell Acute Lymphoblastic Leukemia

This study identifies DPEP1 as a prognostic marker in adult B-cell acute lymphoblastic leukemia, showing its role in proliferation and survival through phosphCREB and p53 regulation.

Phenotypic expansion in DDX3X -- a common cause of intellectual disability in females

The paper identifies additional DDX3X variants in individuals with intellectual disability and expands the known phenotypic spectrum of DDX3X disorders.

Human cytomegalovirus RNA2.7 regulates host cell cycle and facilitates viral DNA replication by inhibiting RNA polymerase II phosphorylation

This study identifies RNA2.7 as a viral long non-coding RNA that inhibits host cell cycle progression and promotes viral DNA replication by blocking RNA polymerase II phosphorylation.

Population Pharmacokinetics Study of Morinidazole in Patients with Moderate Hepatic Impairment

This study builds a population pharmacokinetic model of morinidazole in patients with hepatic impairment and provides dosage adjustment strategies based on covariates like disease status and weight.