A Hybrid Modeling Framework for Predictive Digital Twins of CHO Cell Culture
Anne Richelle, David Andersson, Athanasios Antonakoudis, Jesper Jakobsson, Shanti Pijeaud, Anton Vernersson, Johan Trygg
The paper develops a hybrid modeling framework for predicting CHO cell culture digital twins by integrating ODE models, metabolic constraints, and machine learning trained on Bayesian-estimated metabolic rates.
Computational and Structural Biotechnology Journal · Mar 1, 2026Peer-reviewedBioengineering