Combination spinal cord stimulation at different frequencies produces sustained pain relief with immune activation
Yul Huh, Shaoyong Song, Toby Chen, Tianhe C. Zhang, Brad Hershey, Rosana Esteller, Ru‐Rong Ji
This study shows that dual-frequency spinal cord stimulation produces long-lasting pain relief in rats and mice, associated with immune system activation and specific signaling pathways.
bioRxiv · Aug 12, 2026 · PreprintNeuroscience