Polygenic risk scores associate with asthma phenotypes and proteomic analyses implicate IL1R1 in two family-based studies
Sanghun Lee, Matthew R. Moll, Kevin M. Mendez, Nicole Prince, Jessica Ann Lasky-Su, Sharon M. Lutz, Scott T. Weiss, Christoph Lange, Rachel S. Kelly, J Hecker
This study uses polygenic risk scores and proteomic analysis to identify genetic and molecular associations with asthma in two family-based cohorts, highlighting IL1R1's role in asthma pathogenesis.
medRxiv · Jun 11, 2026 · PreprintGenetic & Genomic Medicine