Investigating curvature sensing by the Nt17 domain of Huntingtin protein
Neha Nanajkar, Abhilash Ku Sahoo, Shelli L. Frey, Silvina Matysiak
This study investigates how the Nt17 domain of huntingtin protein senses curved membranes using molecular dynamics and CD spectroscopy, finding that terminal Phe residues drive curvature preference.
ACS Chemical Neuroscience · Aug 25, 2025Peer-reviewedBiophysics