Single-cell multi-omics analysis reveals heterogeneity and plasticity of neutrophil states in response to immunotherapies
Anqi Gao, Sananda Shyamkumar, Natalie B. Winn, Amy K. Erbe, Shelly M. Davis, Jennifer Zaborek, Kaia Heimstreet, Simon Boyenga, Joel A Matthews, Stella Tzu-Ming Tzu-Ming Tsao, Paul M. Sondel, Huy Q. Dinh
This study identifies treatment-induced neutrophil states in tumors using single-cell multi-omics, showing ICAM1 as a marker of anti-tumor activity and potential biomarker for immunotherapy response.
bioRxiv · Jul 3, 2026 · PreprintCancer Biology