Bispecific GD2xB7-H3 Antibody Improves Tumor Targeting and Reduces Toxicity while Maintaining Efficacy for Neuroblastoma
Amy K. Erbe, Arika S. Feils, Sabrina Reinthaler, Alina A. Hampton, Zachary T. Rosenkrans, Yadira Medina-Guevara, Mildred A. R. Felder, Jessica M. Wiwczar, Daniel Gerhardt, Mark R. Bercher, Belinda B. Wenke, Callie Haertle, Mackenzie Heck, Kaia Heimstreet, Elizabeth Frankel, , PaulM. Sondel
This paper describes a bispecific antibody that targets GD2 and B7-H3 to improve tumor targeting and reduce toxicity in neuroblastoma treatment.
bioRxiv · Sep 22, 2026 · PreprintCancer Biology