Aggrecan hypomorphism accelerates the progression of post-traumatic osteoarthritis in mice
Xujia Wang, Reinhild Hofmann, Bastian Hartmann, Shenxi Zhong, Xiangqing Meng, Heidrun Grondinger, Zsuzsanna Farkas, Riccardo Enzo Giunta, Hauke Clausen‐Schaumann, Attila Aszódi, Paolo Alberton
This study shows that aggrecan hypomorphism in mice accelerates post-traumatic osteoarthritis progression, highlighting aggrecan's role in joint homeostasis.
bioRxiv · Aug 7, 2026 · PreprintMolecular Biology