Plasmid architecture determines the stability of inverted terminal repeats in adeno-associated virus vectors
Vinod Jaskula-Ranga, Sheri Li, Aditya Pandya, Fred Bunz
The paper identifies position-dependent ITR instability in AAV plasmids and develops a stable rAAV vector with full-length native ITRs.
bioRxiv · Sep 28, 2026 · PreprintMolecular Biology