Author

Shijie Zhang

Tianjin Medical University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Genetics· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:deep learning· 2 Research Focus:variant effect prediction· 2 Assay:whole-genome sequencing· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1

Frequent Co-Authors

Dandan HuangiD· 3 shared Mulin Jun LiiD· 3 shared Hongxi YangiD· 2 shared Pak Chung ShamiD· 2 shared Xianfu YiiD· 2 shared Xiaobao DongiD· 2 shared Xutong FaniD· 2 shared Yao ZhouiD· 2 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersGenetics

Dandan HuangORCID

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Author profile →

3 papers

Recent·Most cited

A genomic foundation model for interpreting human genetic diversity

Qinyi Xu, Zhikun Wu, Meijing Dong, Tianpeng Bao, Wenyan ng, Xuanzhao Huang, Hongxi Yang, Yao Zhou, 易显富, Shijie Zhang, Dandan Huang, Pak Chung Sham, Wenhao Zhou, Mulin Jun Li

The paper introduces hEVO, a genomic foundation model trained on human haplotype sequences, achieving top performance in variant interpretation and functional annotation across multiple benchmarks.

bioRxiv · Oct 21, 2026 · PreprintGenomics

Stratifying variant deleteriousness and trait-modulating effect under human recent adaptation

Xutong Fan, Dandan Huang, Xinran Dong, Xianfu Yi, Jianhua Wang, Shijie Zhang, Xiaobao Dong, Xiaoqiong Gu, Miaoxin Li, Pak Chung Sham, Wenhao Zhou, Mulin Jun Li

This study introduces a deep learning framework, FIND, to better classify genetic variants by their deleteriousness and trait-modulating effects, showing improved performance over existing methods.

bioRxiv · Jul 15, 2024 · PreprintGenetics

Unraveling the causal genes and transcriptomic determinants of human telomere length

Ying Chang, Yao Zhou, Junrui Zhou, Wen Li, Jiasong Cao, Yaqing Jing, Shan Zhang, Yongmei Shen, Qimei Lin, Xutong Fan, Hongxi Yang, Xiaobao Dong, Shijie Zhang, Xianfu Yi, Ling Shuai, , Dandan Huang

This study identifies causal genes and transcriptomic factors influencing human telomere length using placental tissue data and GWAS.

Nature Communications · Dec 21, 2023Peer-reviewedGenetics