Xiaoqiong Gu

Single-cell multiomic QTL mapping reveals state-dependent genetic regulation and associated gene during cellular senescence

The paper uses single-cell multiome data to identify QTLs regulating gene expression and chromatin accessibility during cellular senescence, revealing new causal variants and regulatory mechanisms.

Stratifying variant deleteriousness and trait-modulating effect under human recent adaptation

This study introduces a deep learning framework, FIND, to better classify genetic variants by their deleteriousness and trait-modulating effects, showing improved performance over existing methods.

Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity that may underly population disparities in this disease

This study identifies 38 novel SLE loci and shows genetic heterogeneity across ancestral groups, highlighting antibody production as a potential mechanism for disease disparities.

The rs6505162 C>A polymorphism in the miRNA-423 gene exhibits a protective element of coronary artery in a southern Chinese population with Kawasaki disease

The paper investigates the association of miRNA-423 rs6505162 polymorphism with Kawasaki disease susceptibility and coronary artery lesions in a southern Chinese population.