The do not eat me signal CD47 contributes to microglial phagocytosis defects and autism-like behaviors in 16p11.2 deletion mice
Jun Ju, Yifan Pan, Xinyi Yang, Xuanyi Li, Jinghong Chen, Shiyu Wu, Sheng‐Tao Hou
This study shows that increased CD47 in 16p11.2 deletion mice impairs microglial phagocytosis, leading to autism-like behaviors, and that reducing CD47 improves these deficits.
bioRxiv · Jun 7, 2024 · PreprintNeuroscience