Light-dependent induction of Edn2 expression and attenuation of retinal pathology by endothelin receptor antagonists in Prominin-1- deficient mice
Yuka Kobayashi, Shizuka Watanabe, Manabu Shirai, Chiemi Yamashiro, Tadahiko Ogata, Fumiaki Higashijima, Takuya Yoshimoto, Takahide Hayano, Yoshiyuki Asai, Noriaki Sasai, Kazuhiro Kimura
This study identifies Edn2 upregulation in Prom1-deficient mice and shows that endothelin receptor antagonists reduce retinal degeneration.
bioRxiv · Dec 7, 2020 · PreprintNeuroscience