Structural and Thermodynamic Determinants of Anti-PGE2 mAb Specificity
Mitsuaki Sugahara, Hiromichi Saino, Michiyo Takehira, Yuko Kurahashi, Sae Aoyama-Sasabe, Katsuhide Yutani, Naoko Takahashi, Koji Takio, Hideo Ago, Masaki Yamamoto, Masashi Miyano, Shozo Yamamoto
This study identifies structural and thermodynamic factors governing the specificity of an anti-PGE2 mAb for PGE2 and its analogs using crystallography and thermodynamic analysis.
bioRxiv · Dec 12, 2025 · PreprintMolecular Biology