A Regression-based Framework for Scalable Pathway-guided Search in Genome-wide Association Studies.
Shrayashi Biswas, Soumen Pal, Samsiddhi Bhattacharjee
The paper introduces a regression-based framework to enhance GWAS power by incorporating pathway knowledge, showing improved SNP detection while controlling type-1 error.
bioRxiv · Dec 30, 2017 · PreprintGenetics