LINE-1 replication in a mouse TDP-43 model of neurodegeneration marks motor cortex neurons for cell-intrinsic and non-cell autonomous programmed cell death.
Shreevidya Korada, Oliver H. Tam, Hunter C. Greco, Molly Hammell, Josh Dubnau, Roger B. Sher
This study shows that TDP-43 pathology in mice triggers LINE-1 retrotransposon replication in motor cortex neurons and glia, leading to cell-intrinsic and non-cell autonomous programmed cell death.
bioRxiv · Jun 6, 2025 · PreprintNeuroscience