Roger B. Sher

The paper shows that cell-cycle re-entry in motor neurons correlates with distinct ALS outcomes and identifies CDK4/6 inhibition as a potential neuroprotective strategy.

This study shows that TDP-43 pathology in mice triggers LINE-1 retrotransposon replication in motor cortex neurons and glia, leading to cell-intrinsic and non-cell autonomous programmed cell death.

This study shows that nuclear import defects drive cell cycle dysregulation in neurodegeneration by impairing nuclear import pathways and causing cell cycle re-entry in neurons.

The paper identifies cell type-specific senescence-associated transcriptional regulators in midbrain cell lines using PCA and regulatory network inference.

The paper shows that ribosomal quality control factors reduce toxic repeat-associated non-AUG translation from GC-rich repeats by preventing ribosomal stalling.

The paper shows that Importin-β nuclear transport defects cause TDP-43 mislocalization and transcriptional changes linked to neurodegeneration.

This study identifies a gene regulatory pathway involving SATB1, MIR22HG, and GBA that leads to glucocerebroside accumulation and cellular senescence in dopaminergic neurons, contributing to Parkinson's Disease and aging.