Evolutionary Decoding of the Bacillus subtilis Secretome: Insights from Pan-Genomics and Deep Learning
Chong Peng, Chengwu Yuan, Linhao Meng, Yuying Chen, Shuang Wen, Fuping Lu, Yihan Liu
This study uses pan-genomics and deep learning to analyze signal peptides in 287 Bacillus subtilis strains, revealing an open pan-signal peptidome and evolutionary decoupling between signal peptides and mature proteins.
bioRxiv · Dec 22, 2025 · PreprintBioinformatics