Chromosomal rearrangements at hypomethylated Satellite 2 sequences are associated with impaired replication efficiency and increased fork stalling
Yannick Delpu, Thomas McNamara, Patrick T. Griffin, Suhail Kaleem, Shubhada Narayan, Carl L. Schildkraut, Karen H. Miga, Mamta Tahiliani
The paper shows hypomethylation of Satellite 2 sequences impairs DNA replication, leading to chromosomal rearrangements and genomic instability.
bioRxiv · Feb 19, 2019 · PreprintMolecular Biology