Hepatic Differentiation of Human Pluripotent Stem Cells into Functional In Vitro Models Recapitulating Native Liver Complexity for MASLD Modelling
Saloni Sainger, Anshul Chikara, Manisha Kumari, Deepika Kumari, Pratibha Jaipal, Shubhanshi Ranjan, Sunil Gujjar, Yashwant Kumar, A T Rajesh Kumar, Santosh Mathapati
This paper develops a 10-day protocol to differentiate human pluripotent stem cells into hepatocyte-like cells and hepatic liver organoids, showing that organoids better model liver disease features than individual cells.
bioRxiv · Jul 12, 2026 · PreprintCell Biology