Single-cell multi-omics map of human foetal blood in Down's Syndrome
Andrew R. Marderstein, Marco De Zuani, Haoliang Xue, Jon Bezney, Shuo Wong, Tim H. H. Coorens, Stephen B. Montgomery, Ana Cvejic
This study integrates single-cell multi-omics data from human foetal blood to show that trisomy restructures enhancer-gene maps, leading to dysregulated erythroid differentiation and haematological abnormalities in Down's Syndrome.
bioRxiv · Sep 25, 2023 · PreprintGenomics