A GPX4 phosphorylation switch by FGFR1 guards against ferroptosis
Lintao Song, Luyao Wang, Wenliya Dong, Jie Qi, Sisi Zhi, Hongxia Lu, Yang Sun, Siyan Xu, Hou Yushu, Shuliang Tian, Qiyang Qian, Hao Ye, Jiaze Xi, Weinan Liang, Lei Fan, , Lei Fan
This study identifies a phosphorylation switch controlled by FGFR1 that regulates GPX4 activity and protects against ferroptosis in cardiac ischemia/reperfusion injury.
bioRxiv · Oct 26, 2026 · PreprintCell Biology