Dynamic regulation of the Bcl-xL-BAD interaction
Aman Munirpasha Halikar, Aijaz Ahmad Rather, Zion Mercy M, Sivakumar K.C, Thankayyan Retnabai Santhoshkumar
This study uses FLIM-FRET to show that apoptotic stress increases Bcl-xL-BAD interaction, with structural mutants revealing distinct binding requirements and functional outcomes.
bioRxiv · Jun 24, 2026 · PreprintCell Biology