Loss of coactosin-like F-actin binding protein 1 (Cotl1) decreases platelet-mediated osteoclastogenesis and causes osteopetrosis phenotypes in mouse
Eunkuk Park, Seung-Hee Yun, Hyun‐Seok Jin, Chang-Gun Lee, So-Hyun Lee, Seok‐Yong Choi, Hyun Goo Woo, Ji Eun Lim, Bermseok Oh, Seon‐Yong Jeong
This study shows that loss of Cotl1 in mice reduces platelet-mediated osteoclastogenesis, leading to osteopetrosis, and identifies a genetic association between COTL1 variants and bone density in humans.
medRxiv · Dec 20, 2023 · PreprintGenetic & Genomic Medicine