Dual-site specificity of the archaeal tRNA m2G methyltransferase Trm14
Teppei Matsuda, Takashi Yokogawa, Soichiro Hidetaka, Manaka Sora, Aoi Ihara, Ayumu Toba, Kumpei Kawai, Go Norimoto, Akira Hirata, Hiroyuki Hori, Ryota Yamagami
This study shows that the archaeal Trm14 methyltransferase modifies both m2G6 and m2G67 in tRNAs and that these modifications are important for growth at high temperatures.
bioRxiv · Aug 11, 2026 · PreprintMolecular Biology