XL-MS and De Novo Protein Design Identified a Common Motif for TREM2 Binding
Doniesha Perera, Emmanuel Gboyega Ajiboye, Kalana Pitakatuwana, Sophia Wier, Vincent Duong, Haifan Wu
The paper identifies a helix-loop-helix motif in ApoE3 that binds TREM2 using XL-MS and de novo protein design.
ACS Chemical Neuroscience · Sep 17, 2026Peer-reviewedBiophysics