Patient cerebral organoids capture Alzheimers disease proteomic biomarkers and drug targets
Shannon Thomson, Xinran C Li, Sophie Walker, Tiffany C. Y. Tang, Mark Evan Graham, Sam W.Z. Olechnowicz, Rory J. Bowden, Katherine A. Waugh, Chad M Slawson, Jeffrey Murray Burns, Russell Howard Swerdlow, Heather Wilkins, Artur Shvetcov, Caitlin A. Finney
The paper benchmarks proteomic biomarkers and drug targets in patient-derived cerebral organoids against clinical cohorts, finding they detect most candidates and replicate disease changes in a quarter of reproducible markers.
bioRxiv · Jun 26, 2026 · PreprintNeuroscience