Russell Howard Swerdlow

This paper investigates how HSV-1 disrupts mitochondrial function through specific viral proteins, leading to changes that support viral replication while protecting mitochondria from degradation.

The paper benchmarks proteomic biomarkers and drug targets in patient-derived cerebral organoids against clinical cohorts, finding they detect most candidates and replicate disease changes in a quarter of reproducible markers.

The paper shows that diabetes status affects mitochondrial DNA copy number changes in AD brain regions, with non-diabetic AD cases showing reduced mtDNA-CN and diabetic cases showing increased mtDNA-CN.

The paper presents a harmonized framework for analyzing large-scale plasma proteomics data across neurodegenerative diseases, identifying disease-specific circulating signatures and biomarkers.

This paper uses Polygenic Risk Scores and Mendelian Randomization to evaluate the causal effect of mitochondrial DNA copy number on Alzheimer's and Parkinson's disease risk.

This study identifies an APOE4-specific cerebrospinal fluid proteome signature using machine learning, independent of Alzheimer's disease diagnosis and associated with increased risk of cognitive impairment.

This study examines the effects of late-life alcohol exposure on spatial memory and TFEB activity in young and aged mice, finding that aging has a greater impact than alcohol.

The paper uses multi-omics analysis to show OGT regulates aneuploidy by fine-tuning multiple cellular pathways through O-GlcNAcylation.

The paper investigates DNA breaks in Alzheimer's disease brains, finding a loss of adaptive DNA breaks at nervous system genes despite an overall increase in DNA breaks.

The paper investigates the association between mitochondrial genome abundance and Alzheimer's disease, finding lower abundance correlates with worse neuropathology and cognitive performance.

The paper compares miRNA expression in synaptosomes and cytosol from AD and control brains, identifying differentially expressed miRNAs and their potential roles in synapse function.

The paper develops a method to impute missing mitochondrial DNA variants using a large reference alignment, improving haplogroup assignment and enabling better integration of mtDNA data from different sources.

The paper investigates mitochondrial pathway polygenic risk scores and finds associations with increased Alzheimer's Disease risk in a cohort from the Alzheimer's Disease Neuroimaging Initiative.

The paper investigates how mitochondrial DNA haplogroups and a polygenic risk score interact to influence dementia risk and age of onset.