CRISPR correction of GBA mutation in hiPSCs restores normal function to Gaucher macrophages and increases their susceptibility to Mycobacterium tuberculosis
Sivaprakash Ramalingam, Amit Kumar, Stefanie Krug, Harikrishnan Mohan, Desirazu Narasimha Rao, William R. Bishai, Srinivasan Chandrasegaran
This study corrects GBA mutations in hiPSCs to restore macrophage function in Gaucher disease and shows increased susceptibility to Mycobacterium tuberculosis.
bioRxiv · Nov 26, 2022 · PreprintGenomics