Let-7 restrains an oncogenic circuit in AT2 cells to prevent fibrogenic cell intermediates in pulmonary fibrosis
Matthew J. Seasock, Md Shafiquzzaman, Maria Elisa Ruiz Echartea, Rupa S. Kanchi, Brandon T. Tran, Lukas Mikolaj Simon, Matthew D. Meyer, Phillip A. Erice, Shivani L. Lotlikar, Stephanie C. Wenlock, Scott A. Ochsner, Anton James Enright, Alexandre F. Carisey, Freddy Romero, Iván O. Rosas, , Antony Rodriguez
This study identifies let-7 as a regulator of AT2 cell differentiation and fibrosis prevention by controlling oncogenic networks and epigenetic changes.
Nature Communications · May 10, 2025Peer-reviewedCell Biology