Tau modulates mRNA transcription, alternative polyadenylation profiles of hnRNPs, chromatin remodeling and spliceosome complexes
Mauro Montalbano, Elizabeth A. Jaworski, Stephanie García, Anna Ellsworth, Salomé McAllen, Andrew L. Routh, Rakez Kayed
This study investigates how WT and P301L tau proteins modulate transcription and alternative polyadenylation profiles in neuronal cells, revealing distinct gene expression changes related to chromatin remodeling and splicing.
Frontiers in Molecular Neuroscience · Dec 3, 2021Peer-reviewedNeuroscience