The Human Pleiotropic Map of GWAS Associations and Therapeutic Implications
Yakov A. Tsepilov, Dániel Süveges, Daniel Considine, Szymon Szyszkowski, Xiangyu Jack Ge, Irene López Santiago, Polina V. Rusina, Tobi Alegbe, Vivien W. Ho, Kirill Tsukanov, Juan María Roldán‐Romero, Ines A. Smit, Helena Cornu, Laura Wiseman Harris, Kaur Alasoo, , David Ochoa
This paper analyzes 100,526 GWAS to identify pleiotropic genes and their therapeutic implications, finding that highly pleiotropic genes are associated with safety liabilities and that combining PAV support with intermediate pleiotropy improves therapeutic success.
bioRxiv · May 1, 2026 · PreprintGenomics