Xiangyu Jack Ge

This paper analyzes 100,526 GWAS to identify pleiotropic genes and their therapeutic implications, finding that highly pleiotropic genes are associated with safety liabilities and that combining PAV support with intermediate pleiotropy improves therapeutic success.

This study analyzes ancient DNA to reveal the 2500-year evolutionary history of human betaherpesviruses 6A and 6B, showing established diversity by the 14th century and ancient integration into the human genome.

This study analyzes ancient genomes from Cambridgeshire to assess the Black Death's impact on local genetic diversity and social structure, finding no major genetic changes but disparities in stature linked to social status.

This study evaluates very low depth whole genome sequencing for complex trait association studies, showing it can efficiently discover association signals comparable to imputed GWAS chip designs.