A Cre-Driver Rat Model for Anatomical and Functional Analysis of Glucagon (Gcg)-Expressing Cells in the Brain and Periphery
Huiyuan Zheng, Lorena López‐Ferreras, Jean-Phillipe Krieger, Stephen Fasul, Valentina Cea Salazar, Natalia Valderrama Pena, Karolina Patrycja Skibicka, Linda Rinaman
This paper develops a Gcg-Cre rat model to study GLP1-expressing cells in the brain and periphery, finding that homozygous rats show reduced Gcg mRNA and GLP1 protein, and chemogenetic activation suppresses food intake.
Molecular Metabolism · Nov 8, 2022Peer-reviewedNeuroscience