The 3' Region of the ZPA Regulatory Sequence (ZRS) is required for activity and contains a critical E-box
Kathryn F. Ball, Stephen Manu, Abbie K. Underhill, Jeanyoung Kim, Jessica C. Britton, Sarah R. Rudd, Madison M. Malone, Japhet Amoah, Allen M. Cooper, Charmaine U. Pira, Kerby C. Oberg
The paper identifies the 3' E-box in the ZRS as critical for enhancer activity and shows that Hoxd13 sites localize activity to the ZPA.
Frontiers in Cell and Developmental Biology · Jul 2, 2025Peer-reviewedDevelopmental Biology