Ataxin-2 Coordinates Neuronal and Glial Pathways to Promote Neuroprotection
Denise Gastaldo, Steve Vito, Holly Black, Oded Foreman, Zhichang Yang, Victoria C. Pham, Ying Zhu, Meena Choi, Ana Jovičić
This study identifies how ataxin-2 reduction promotes neuroprotection by activating metabolic programs in neurons and astrocytes, enhancing energy production and trophic support.
bioRxiv · Nov 24, 2025 · PreprintNeuroscience