Integrative single cell analysis of CD8+ T-cells across early and advanced oral cancers reveals signatures of anti-tumour activity
Constance H. Li, Hong Sheng Quah, Camille Arcinas, Lakshmi Alagappan, Lisda Suteja, Hariraman Bhuvaneswari, Hui Sun Leong, Fui Teen Chong, Darren Toh, Sophia Wong, Subhra Kumar Biswas, Cliburn C. W. Chan, Narayanan Gopalakrishna Iyer
This paper identifies a signature of anti-tumour activity in CD8+ T-cells across oral cancers using single-cell RNA and TCR sequencing, and develops a machine learning classifier to detect these cells from transcriptome data.
bioRxiv · Sep 3, 2026 · PreprintCancer Biology