Constance H. Li

Integrative single cell analysis of CD8+ T-cells across early and advanced oral cancers reveals signatures of anti-tumour activity

This paper identifies a signature of anti-tumour activity in CD8+ T-cells across oral cancers using single-cell RNA and TCR sequencing, and develops a machine learning classifier to detect these cells from transcriptome data.

Sex Differences in the Cancer Proteome

The paper quantifies sex differences in the cancer proteome across eight cancer types, identifying sex-differential protein abundance and linking some differences to copy number aberrations.

Sex Differences in Cancer Functional Genomics: Gene Dependency and Drug Sensitivity

The paper investigates how patient sex affects cancer cell function by analyzing gene essentiality and drug sensitivity across 1,209 cell lines.

iSubGen: Integrative Subtype Generation by Pairwise Similarity Assessment

iSubGen generates disease subtypes by integrating multiple data types, handling missing data and identifying clinically distinct patient groups.

Accurate Reference-Free Somatic Variant-Calling by Integrating Genomic, Sequencing and Population Data

S22S is a reference-free method for somatic variant calling that uses genomic and population data to accurately identify SNVs without matched normal samples.