Beyond Gatekeeping: Efflux Pumps Remotely Destabilize Cytoplasmic Drug-Target Interactions by Limiting Rebinding.
Subrata Dev, Keiran Stevenson, Le Dai, Minsu Kim
The paper shows efflux pumps reduce drug-target binding affinity by limiting rebinding, not just by reducing drug entry, thereby enhancing multidrug resistance.
bioRxiv · Aug 6, 2025 · PreprintMicrobiology