Uterine-specific SIRT1 deficiency confers premature uterine aging and impairs invasion and spacing of blastocyst and stromal cell decidualization in mice.
Magdalina J Cummings, Hongyao Yu, Sudikshya Paudel, Guang Hu, Xiaoling Li, Myriam Hemberger, Xiaoqiu Wang
This study shows that uterine-specific SIRT1 deficiency in mice leads to premature uterine aging, impaired blastocyst invasion, and defective decidualization, linking these issues to hormonal signaling and epigenetic changes.
Molecular Human Reproduction · May 7, 2022Peer-reviewedGenetics