Guang Hu

The paper identifies a transitional stage in breast cancer metastasis characterized by malignant epithelial diversification and inflammatory neutrophil remodeling, linking these to poor clinical outcomes.

The paper develops a serum-free 6iL/E4 culture system that enables derivation and maintenance of embryonic stem cells (ESCs) across multiple mammalian species, revealing conserved mechanisms for ESC self-renewal.

This study shows that CNOT3 is essential for maintaining spermatogonial stem cells in mice by repressing differentiation factors and regulating the redox pathway.

This paper shows that selective GSK3 inhibition with BRD0705 supports self-renewal of mouse stem cells and enables co-culture of naive and primed stem cells while preserving their identities.

The paper shows that RNA stability controls neurogenesis in the developing cortex by regulating gene expression through the CCR4-NOT complex.

This study shows that uterine-specific SIRT1 deficiency in mice leads to premature uterine aging, impaired blastocyst invasion, and defective decidualization, linking these issues to hormonal signaling and epigenetic changes.

The paper shows that apoptosis in the fetal mouse testis removes developmentally defective germ cell clones based on intrinsic properties and epigenetic states.

This study shows that loss of Coq10a, a muscle-enriched mitochondrial protein, enhances postnatal cardiac hypertrophy without impairing cardiac function.