Spatial and Single-Cell Dissection of Fibroblast Subpopulation Reprogramming Driving Stromal Collapse in Breast Cancer Lymph Node Metastasis
Hadith Rastad, Mahnaz Seifi Alan, Mahin Seifi Alan, Sumeet pandey
This study identifies three downregulated genes in breast cancer lymph node metastasis and shows their fibroblast-specific roles in maintaining stromal barriers, with therapeutic implications.
bioRxiv · Aug 18, 2025 · PreprintGenetics