Author

Mahnaz Seifi Alan

Alborz University of Medical SciencesORCID 0000-0003-1882-5951Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:machine learning (classical)· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Hadith RastadiD· 2 shared Mahin Seifi Alan· 2 shared Azadeh Jalilian· 1 shared Haniyeh Rashidi· 1 shared Kobra Hosseini· 1 shared Sanaz Seifi-Alan· 1 shared Sedighe Hoseini· 1 shared Sumeet pandey· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 23 mutual co-author links

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2 shared papersGenetics

Hadith RastadORCID

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2 papers

Recent·Most cited

GeneticsbioRxivPreprintAug 18, 2025

Spatial and Single-Cell Dissection of Fibroblast Subpopulation Reprogramming Driving Stromal Collapse in Breast Cancer Lymph Node Metastasis

Hadith Rastad, Mahnaz Seifi Alan, Mahin Seifi Alan, Sumeet pandey

This study identifies three downregulated genes in breast cancer lymph node metastasis and shows their fibroblast-specific roles in maintaining stromal barriers, with therapeutic implications.

DOI 10.1101/2025.08.18.670793

humanbulk RNA-seq

𝕏 PostBluesky

GeneticsbioRxivPreprintAug 18, 2025

Unveiling Novel Molecular Drivers in Breast Cancer Brain Metastasis: Multi-Omics Integration Identifies Downregulation of VCAN and Emerging Roles of ASCL2/GRAMD1A as Prognostic Biomarkers and Therapeutic Vulnerabilities

Hadith Rastad, Mahin Seifi Alan, Azadeh Jalilian…·Mahnaz Seifi Alan

This paper identifies key molecular drivers of breast cancer brain metastasis through multi-omics analysis and proposes therapeutic strategies based on gene and miRNA dysregulation.

DOI 10.1101/2025.08.18.670830

humanbulk RNA-seq

𝕏 PostBluesky